| Registro completo |
| Provedor de dados: |
BJID
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| País: |
Brazil
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| Título: |
Therapy with interferon-alpha plus ribavirin for membranoproliferative glomerulonephritis induced by hepatitis C virus
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| Autores: |
Lopes,Edmundo P.A.
Valente,Lucila M.
Silva,A. Eduardo B.
Kirsztajn,Gianna Mastroianni
Cruz,Cibele N.
Ferraz,Maria Lucia G
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| Data: |
2003-10-01
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| Ano: |
2003
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| Palavras-chave: |
Glomerulonephritis
Hepatitis C
Interferon
Ribavirin
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| Resumo: |
We describe a treatment made with interferon-alpha (IFN-alpha) plus ribavirin of two patients with membranoproliferative glomerulonephritis (MPGN) induced by hepatitis C virus (HCV): Case 1 was a 22-year-old woman with leg and facial edema, hypertension and proteinuria, whose liver biopsy revealed chronic active hepatitis; and Case 2 was a 42-year-old man with anasarca, hypertension and proteinuria, whose liver biopsy indicated cirrhosis. Both had anti-HCV, HCV-RNA and cryoglobulins. IFN-alpha (3 million units (MU), 3 times/week) and ribavirin (1 g/day) were administered for 12 months. The drugs were well tolerated by both patients. Serum alanine aminotransferase (ALT) levels normalized and HCV-RNA became negative. Cryoglobulins disappeared and an improvement in renal disease was seen after 6 months of therapy. However, after 9 months, Case 2 presented ALT elevation, and proteinuria was detected. Two years after the end of therapy, both patients were negative in repeated HCV-RNA and cryoglobulin tests. Case 1 was asymptomatic, with normal liver and renal tests, and Case 2 had normal blood pressure, with mild edema of the ankles. Based on the evolution of these two cases, the association of IFN-alpha and ribavirin may be a therapeutic option for patients with MPGN related to HCV.
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| Tipo: |
Info:eu-repo/semantics/report
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702003000500011
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| Editor: |
Brazilian Society of Infectious Diseases
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| Relação: |
10.1590/S1413-86702003000500011
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| Formato: |
text/html
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| Fonte: |
Brazilian Journal of Infectious Diseases v.7 n.5 2003
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| Direitos: |
info:eu-repo/semantics/openAccess
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